Fri Sep 12 2025

35 articles - From Friday Sep 05 2025 to Friday Sep 12 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

J Crohns Colitis

Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease.

Overall, the goal of the group was to provide data-driven and practical guidance to improve the care of women with IBD around the globe based on the best available research.

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Meta-analysis

meta-analyses and systematic reviews

Am J Clin Nutr

Effects of carbohydrate-restricted diets and macronutrient replacements on cardiovascular health and body composition in adults: A meta-analysis of randomized trials.

CRDs improved cardiovascular health and body composition, especially in diets with combined macronutrient replacement. Potential adverse effects, including LDL elevation and lean mass loss, warrant clinical monitoring. Registration number For body composition PROSPERO CRD420251043066 ( for cardiovascular health CRD420251011748 (

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Associations of body mass index, waist circumference, and weight-adjusted waist index with body composition and biomarkers: A multinational pooled analysis.

Our data suggest that WWI is associated with unhealthy body composition (high fat, low fat-free mass) in populations of diverse age, sex, and race/ethnicities and may serve as an alternative index to BMI and WC.

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Can correction of low vitamin D status in infancy program for a leaner body composition?: a post-trial follow-up study of whole body lean mass in early childhood.

The greater whole body lean mass observed in infants in our published trial of 1000 IU/d of vitamin D supplementation compared to 400 IU/d was maintained post-trial at 24 months in accordance with greater length. Confirmation of these observations, and whether these extend into later childhood, requires new trials.

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Impact of sustainable diets on micronutrient intakes and status: outcomes of the MyPlanetDiet randomized controlled trial.

A diet based on sustainable dietary principles lowered dietary GHGE and several MNs, despite provision of daily servings of dairy, three weekly servings of animal protein and two servings of fish. These findings show that MNs should be considered in developing environmentally protective diets. Clinical trial registry (NCT05253547).

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Ingestion of a lipid-rich meat matrix blunts the post-exercise increase of myofibrillar protein synthesis rates in healthy adults: A randomized controlled trial.

Clinical trial registry NCT05876299, ClinicalTrials. gov.

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Interaction between dietary cholesterol intake and genetic variants for cholesterol absorption in relation to coronary artery disease mortality: a prospective analysis in the Singapore Chinese Health Study.

DC intake was more strongly associated with CAD mortality in Singapore Chinese with greater genetic susceptibility to cholesterol absorption.

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Predicting total body water in infants aged 0.5-24 months and the implications for measuring breast milk intake: a secondary analysis of isotope dilution data.

The equation used in DTM calculations provides biased TBW estimates. This has implications for measuring breast milk intake and nonmilk water intake and our understanding of nutritional needs during the first 2 y of life.

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The effect of muscle quality index on the risk of adverse health outcomes: a prospective cohort study of 355,209 adults.

Our findings highlight the importance of enhancing muscle quality to prevent chronic diseases and unveil underlying mechanisms.

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Inflamm Bowel Dis

Branched-Chain Amino Acids Exacerbate Colitis Progression by Lowering Colonic Fumarate Levels.

BCAA supplementation exacerbates DSS-induced colitis in mice. This effect is mediated by detrimental changes in gut microbiota composition and metabolome. DMF treatment shows promise to mitigate these adverse effects, suggesting potential therapeutic avenues to manage BCAA-induced colitis exacerbation and reinforcing the role of microbiome in UC. These findings underscore the caution needed with the use of BCAAs during inflammatory conditions.

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Clinical Research: Disparities in Outcomes for Patients With Inflammatory Bowel Disease at a Private vs Public Hospital in New York City.

Our study is the first to identify significant differences in patient demographics, disease phenotype, treatments and clinical outcomes between patients treated for IBD at a private nonprofit vs public hospital. Our data suggest that social determinants of health drive disparities in the utilization of healthcare facilities.

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Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis.

In summary, this work highlights the importance of personalized investigation of signaling processes upstream of genetic polymorphisms to gain a more comprehensive understanding of IBD pathogenesis.

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The Impact of Sarcopenia on Clinical Outcomes in Pediatric Crohn's Disease.

The presence of sarcopenia at the diagnosis increases the risk of clinical relapses in the first year of diagnosis. Magnetic resonance evaluation of the tPMA could therefore help identify children at higher risk of worse outcomes.

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When to Switch to Subcutaneous Infliximab? The RE-WATCH Multicenter Study.

Our study has shown that early switch from IV-IFX to SC-IFX at 6 weeks is effective in terms of clinical and endoscopic remission at one year yielding similar results to late switch at 6 months.

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J Crohns Colitis

Blood proteomic signatures associated with disease activity in Inflammatory Bowel Diseases.

Our findings reveal inflammatory blood proteomic signatures associated with post-operative recurrence and biologic treatment failure in IBD. Several key biomarkers were identified. These results support the rationale for personalized approaches, including combination therapies targeting multiple pathways.ClincialTrials.gov number, NCT02693340 and NCT02693340.

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Clinical Outcome After Entero-Enteric Anastomosis for Crohn's Disease: A Case-Control Study.

The clinical outcome is more severe in CD patients with EEA than in those with ICA, being associated with a higher rate of clinical recurrence and hospitalization after surgery.

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Subcutaneous vedolizumab dose intensification in inflammatory bowel disease patients: the OPTI-VEDO multicenter study from the GETAID.

In this real-world study evaluating SC VDZ intensification, a SFCr was observed in at least one third of IBD patients at 3 months, suggesting the benefit of this strategy in clinical practice.

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Unravelling the genetic architecture of inflammatory bowel disease multiplex families with rare and common variant polygenic risk scores.

Multiplex IBD families show diverse genetic architecture, with almost half showing a high burden of common and/or rare risk variants. While genetic predispositions to smoking influences IBD risk in sporadic cases, it provides limited insights into familial IBD. These findings highlight the genetic complexity within multiplex families and the need for tailored research approaches such as risk stratification and genetic screening strategies.

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Pancreatology

GALNT4-induced O-GalNAc glycosylation of MUC1 accelerates the invasive phenotype of PDAC.

GALNT4-induced O-GalNAc glycosylation of MUC1 accelerates the formation of the invasive phenotype in PDAC, which could be a potential target for novel treatment.

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Outcomes of FOLFIRINOX versus gemcitabine plus nab-paclitaxel in patients with early recurrent pancreatic cancer after adjuvant S-1 treatment: A propensity score-matched analysis.

GnP was associated with improved OS compared to FOLFIRINOX for patients with early recurrence after adjuvant S-1.

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Prediction model for mutation detection via circulating tumor DNA analysis in pancreatic cancer.

We developed and validated a predictive model for KRAS mutations. This model may be a useful clinical decision-making tool for liquid CGP in patients with PC.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

A scoping review on the possible immunometabolic properties of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid.

Epidemiological evidence further supports that elevated CMPF levels are associated with reduced susceptibility to infections. Collectively, there is compelling evidence supporting the hypothesis that CMPF is a bioactive metabolite with systemic metabolic and immunomodulatory effects, warranting further in-depth investigation.

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In pursuit of perfection: a small but important refinement of the isotopic measurement of human milk output.

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Rising global burden of sugar-sweetened beverage consumption- Urgent need for action.

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Pancreatology

Defining oligo-recurrence criteria for locoregional intervention in pancreatic ductal adenocarcinoma: A multidisciplinary era perspective.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Clin Nutr

Reanalysis of the vitamin D and dementia association using the doubly-ranked nonlinear Mendelian randomization approach.

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Liver Transpl

Letter to the editor: Clarifying skin cancer definitions and time frames in liver transplant recipients.

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Workload, compensation, and institutional support among U.S. transplant hepatologists: Results of a National Survey.

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Pancreas

Poor Performance Status, Diabetes Mellitus, and Statin use are Risk Factors for Decreased Skeletal Muscle Mass During Nab-paclitaxel Plus Gemcitabine Therapy in Patients with Advanced Pancreatic Cancer.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

Calling Guidance Evidence-Based When It Is Not Is Against the Ethos of Science.

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Establishing minimal reporting standards for unknown metabolites: an essential prerequisite for advancing nutritional metabolomics.

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Revised analyses do not provide compelling evidence of any benefit of vitamin D.

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Skeletal Muscle and Fat-Free Mass: Related but Distinct Concepts in Body Composition.

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We need to bridge nutritional and pharmacological research for long-term successful implementation of weight loss medication in practice.

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Pancreatology

Letter to the Editor regarding "Predictors of acute pancreatitis in patients treated with GLP-1 receptor agonists for weight management".

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